NIG Iwasato Laboratory

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Neuronal circuit development and function in the mouse brain

@To understand development of complex yet sophisticated neuronal circuits underlying higher brain function of mammals, integrative studies which cover from molecules to whole animals are indispensable. By using a wide range of techniques, such as mouse genetics (gene knockout), 2-photon microscopy, confocal microscopy, histology and behavioral analyses, we are studying mechanisms of development and function of mammalian neuronal circuits.

 

Specific Aims:
Activity-dependent development of neural circuits in the neocortex:

We are using mouse somatosensory cortex as an ideal model system of activity-dependent circuit maturation.

Roles of RacGAP ƒΏ-chimerin in neural circuit development and function:

We are studying roles of ƒΏ-chimerin in various aspects of neuronal circuit development and function such as axon guidance, synapse formation and learning and memory.

 

 

Selected Publications@@

@@@FSOKENDAI graduates


Nakazawa, et al., J. Neurosci. 40, 7637-7650 (2020)
Nakazawa, Mizuno, Iwasato, Nature Communications, 9, 3106 (2018)
Mizuno, Ikezoe, Nakazawa et al., Cell Rep. 22, 123-135 (2018)
Katori et al., J. Neurosci. 37, 7682-7699 (2017)
Luo, Mizuno, Iwata, Nakazawa et al., Sci. Rep. 6, 35747 (2016)
Iwata et al., J. Neurosci. 35, 13728-13744 (2015)
Suzuki et al., Neuroscience 290, 518-529 (2015)
Iwata et al., Cell Rep. 8, 1257-1264 (2014)
Mizuno, Luo et al., Neuron 82, 365-379 (2014)@
Arakawa, Suzuki et al., J. Neurosci.34, 12001-12014 (2014)
Iwasato, T. et al., J. Neurosci. 28, 5931-43. (2008)
Iwasato, T. et al., Cell 130, 742-753 (2007)
Iwasato, T. et al., Nature 406, 726-731 (2000)
Iwasato, T. et al., Neuron 19, 1201-1210 (1997)
Iwasato, T. et al., Cell 62, 143-149 (1990)
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Photo by Dr. Hye-Soo@Kim


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