Neuronal circuit development and function in the mouse brain
To understand development of complex yet sophisticated neuronal circuits underlying higher brain function of mammals, integrative studies which cover from molecules to whole animals are indispensable. By using a wide range of techniques, such as mouse genetics (gene knockout), 2-photon microscopy, confocal microscopy, histology and behavioral analyses, we are studying mechanisms of development and function of mammalian neuronal circuits.Specific Aims:
Activity-dependent development of neural circuits in the neocortex:We are using mouse somatosensory cortex as an ideal model system of activity-dependent circuit maturation.
Roles of RacGAP α-chimerin in neural circuit development and function:
We are studying roles of α-chimerin in various aspects of neuronal circuit development and function such as axon guidance, synapse formation and learning and memory.
Selected Publications
：SOKENDAI graduates
Banerjee, et al., Sci. Rep. 12, 16311 (2022)
Nakazawa, et al., J. Neurosci.40, 7637-7650 (2020)
Nakazawa, Mizuno, Iwasato, Nature Communications, 9, 3106 (2018)
Mizuno, Ikezoe, Nakazawa et al., Cell Rep. 22, 123-135 (2018)
Katori et al., J. Neurosci. 37, 7682-7699 (2017)
Luo, Mizuno, Iwata, Nakazawa et al., Sci. Rep. 6, 35747 (2016)
Iwata et al., J. Neurosci. 35, 13728-13744 (2015)
Suzuki et al., Neuroscience 290, 518-529 (2015)
Iwata et al., Cell Rep. 8, 1257-1264 (2014)
Mizuno, Luo et al., Neuron 82, 365-379 (2014)
Arakawa, Suzuki et al., J. Neurosci.34, 12001-12014 (2014)
Iwasato, T. et al., J. Neurosci. 28, 5931-43. (2008)
Iwasato, T. et al., Cell 130, 742-753 (2007)
Iwasato, T. et al., Nature 406, 726-731 (2000)
Iwasato, T. et al., Neuron 19, 1201-1210 (1997)
Iwasato, T. et al., Cell 62, 143-149 (1990)
Photo by Dr. Hye-Soo Kim
